InterSystems provides advanced data management and interoperability solutions, with products including InterSystems IRIS, a comprehensive data platform designed for high-performance analytics and application development, and InterSystems HealthShare, which facilitates health information exchange and data integration across various systems. InterSystems also offers TrakCare, an integrated healthcare information system that connects care teams and improves patient outcomes

Mirth Connect is an open-source integration engine that facilitates exchange of healthcare data between disparate formats, supporting standards like HL7, DICOM, and XML.

Health Gorilla's HIE facilitates data exchange via web app and API, and ensures compliance with both national and state regulations, including CalHHS DxF and TEFCA. It includes features a processing engine to enrich and normalize data, a national Master Patient Index, and Record Locator Service to ensure data is attributed to the correct patient. The platform supports the exchange of complete data with national and state networks, aiding in enriching current patient data and supporting public health initiatives.